Las Vegas Raiders at LA Chargers odds, picks and predictions Week 2 NFL
Chargers vs. Raiders Week 2 Preview, Odds and Prediction
AFC West rivals square off Sunday afternoon when the Las Vegas Raiders (1-0) visit the Los Angeles Chargers (0-1) at SoFi Stadium in Inglewood, California. Kickoff is scheduled for 4:05 p.m. ET on CBS.
Las Vegas enters Week 2 looking to build on a strong opening victory, while Los Angeles will try to rebound after a disappointing start to the season.
Chargers vs. Raiders Odds
Point Spread: Chargers -6.5
Los Angeles is laying 6.5 points at home, making the Chargers a sizable favorite against their division rival.
Moneyline: Chargers -325 | Raiders +260
The moneyline also strongly favors Los Angeles. Bettors backing Las Vegas would receive the larger potential payout if the Raiders can pull off the road upset.
Over/Under: 43.5
Oddsmakers have placed the game’s combined scoring total at 43.5 points.
How to Watch Raiders vs. Chargers
- Date: Sunday, September 20, 2026
- Kickoff: 4:05 p.m. ET
- TV: CBS
- Streaming: Fubo
- Streaming: Paramount+
- Location: Inglewood, California
- Venue: SoFi Stadium
Raiders vs. Chargers Matchup
The Chargers have controlled this rivalry recently, winning four consecutive meetings and covering the spread in all four.
Los Angeles, however, comes into this game needing a response after falling 26-14 to Arizona as a 9.5-point favorite in its opener. Wide receiver Ladd McConkey provided one of the bright spots with five receptions for 82 yards and a touchdown, although a rib injury has put his availability for Week 2 in question.
Las Vegas had a much better start, defeating Miami 27-13 and covering as a 3.5-point favorite. Kirk Cousins threw three touchdown passes in his Raiders debut, while Ashton Jeanty delivered a major performance out of the backfield with 102 rushing yards. Jeanty also caught six passes for 45 yards and scored twice.
Betting Trends
Los Angeles Chargers
- Los Angeles finished last season 9-8 against the spread.
- The Chargers went 1-1 ATS when favored by at least 6.5 points.
- Six of their 17 games finished above the posted total.
Las Vegas Raiders
- Las Vegas covered the spread seven times in 17 games last season.
- When receiving 6.5 or more points, the Raiders posted a 3-4 ATS record.
- Eight of their 17 games went over the total.
Injury Report
Raiders
- CB Darien Porter: foot, out
- TE Brock Bowers: knee, doubtful
- QB Aidan O’Connell: personal, questionable
Chargers
- CB Elijah Molden: hamstring, out
- OT Trey Pipkins: knee, out
- CB Deane Leonard: abdomen, questionable
- WR Ladd McConkey: rib, questionable
The status of McConkey is particularly important for Los Angeles. His absence would remove one of the Chargers’ primary receiving weapons and could give the Raiders a better opportunity to remain within the number.
Chargers vs. Raiders Prediction
Prediction: Chargers 26, Raiders 20
Los Angeles has the advantage of playing at home and has enjoyed plenty of recent success against Las Vegas. Still, laying 6.5 points with a Chargers team coming off a double-digit home defeat creates some hesitation.
The Raiders looked considerably sharper in their opener, and getting nearly a touchdown with Las Vegas provides some value in what could remain competitive into the fourth quarter.
Rather than paying the expensive price attached to the Chargers moneyline, the more appealing side is Raiders +6.5.
The total is tougher to call. Recent meetings in Los Angeles have generally trended toward lower scoring, but a number of 43.5 leaves room for these offenses to push the game into the mid-40s. A small lean toward the Over 43.5 makes sense, although the spread offers the stronger betting angle.
Best Bet
Raiders +6.5
Final Score Prediction
Chargers 26, Raiders 20
